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Senior Engineering Manager, Automation at Synthego
Redwood City, CA, US
Synthego’s Engineering team prides itself on its breadth of skill sets and expertise that are largely responsible for new product and infrastructure development. To accomplish this, the team combines engineering, automation, and science to solve the problems that no one discipline could tackle alone. 
As a Senior Engineering Manager, Automation within Synthego’s Systems Engineering Team, you will apply your management and technical background to guide liquid handling, laboratory automation, and integration projects from initial conception through development and into production. You will be heavily involved in the full design process from requirements gathering through to validation and delivery, ensuring our entire facility is well documented, fit-for-purpose, and scalable.

What You'll do

      • Liquid-handling expertise, writing complex Hamilton methods for walk-away execution
      • Creating a good design of the experiment to characterize the robustness of a variety of equipment and processes
      • Building-integrated systems / workcells in order to execute the process with maximal efficiency
      • Designed, built and released large scale work-cells into production/regulated environment (1M+ capital projects) 
      • Can move equipment through our process of development and production launch. Includes robust qualification/validation of instruments, full life-cycle specifications, and knowledge of IQ/OQ/PQ
    • Design and deploy multi-million dollar laboratory automation workcells to solve bleeding-edge genome engineering challenges
    • Lead and mentor a group focused on:Implementing components from engineering team as prototype “builds”, transitioning them to robust solutions for production
    • Coordinate with a variety of lab equipment vendors and internal engineering teams to create integrated (system or work cell) solutions
    • Work with process engineering to plan development projects (CapEx and efficiency gains) in order to support demand forecasts
    • Design and execute studies and data gathering exercises with the aim of improving new and existing protocols for use in a high-throughput automated lab
    • Create a broad set of analytical tools/engineering controls and use them to make targeted improvements to automated systems across multiple labs/environments
    • Maintain expertise on alternate methods, techniques and best practices used in the field; routinely benchmark process performance
    • Evaluate critical tradeoffs and make decisions on resource requirements and allocations to set high-level initiative goals
    • Handle multiple projects, seeing obvious overlaps to make the implementation process more efficient and standardized
    • Gather requirements create specifications, and document appropriately
    • Ensure all work and results are recorded suitably for regulatory compliance
    • Lead the software integration of the products and protocols you develop: In a large-scale, distributed, fully-automated genome factory, centralization of data is critical
    • Evaluate new technology to solve challenges posed by adaptation of new product to our commercial pipeline

About You

    • Masters or PhD (preferred) in a Life / Physical Science or Engineering
    • 7+ years of experience investigating, developing, and implementing integrated laboratory or manufacturing processes
    • 3+ years of managing a technical team of scientists/engineers in laboratory automation
    • Air gaps, aspiration speeds, and general discussions surrounding the dark arts of liquid handling are familiar friends - Hamilton (preferred), Tecans, or Beckmans; you’ve tamed them all
    • You understand how to import robust validations/qualifications are to the life-cycle of a product - IQ/OQ/PQ aren’t just letters, they are a way of life
    • You’ve designed, developed and released large work-cells into production/regulated environments (1M+ capital projects)
    • You are familiar with the experimental and documentation overheads that come with being in a regulatory environment (cGxP, CLIA, CAP, ISO)
    • Mechanical, Electrical, Software, or Process - you can follow a broad range of topics within the engineering family, and know-how to spot the gaps between the disciplines
    • Extensive experience integrating laboratory equipment into laboratory information management systems (LIMS)
    • You’ve seen a team created, guided it through getting to know itself, and taken the time to understand what drives its members
    • Multiple, large-sized (year-long) projects running at the same time is something you are used to, both as a key individual contributor and as project coordinator, and you’re looking to take on more
    • You have the ability to work diligently with minimal supervision and take initiative to drive project deadlines
    • You are meticulous in capturing goals, to-dos, and decisions made for yourself and those around you
    • You can work independently but consider yourself to be a team player

Nice to Have

    • You can provide evidence of working with Biology / Chemistry at scale
    • Project management experience
    • Direct engineering experience building instruments and custom solutions (MechEng / ElecEng)
Synthego’s vision is to turn biology into an information science, with the ultimate goal of dramatically extending the healthy human lifespan.
Synthego builds advanced bioinformatics and automated hardware platforms to create next-generation molecular biology tools, starting with full-stack genome engineering.
These world-class tools accelerate basic scientific discovery, critical disease cures and novel synthetic biology applications to improve and prolong life.