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Scientist, Custom Engineered Cells at Synthego
Redwood City, CA, US
Synthego is enabling genome engineering at scale with a blend of scientific instrumentation, industrial automation, and data science. Our team of scientists and engineers are putting multidisciplinary fields together to solve problems that no one field could tackle alone.
We are currently searching for a Scientist for our Custom Engineered Cells program. This role will be responsible for the generation of custom cell lines using Synthego’s genome engineering tools and technologies. 
This role is hands-on in our Production Operations team, lab-based, and will work closely and mentor a supporting team of Cell Culture Specialists and Research Associates. 
This role will be responsible for solving challenging genome engineering problems, ensuring processes are executed correctly while working to develop new and improved protocols, instrumentation, and assays. The projects involved are Production orders, for which turnaround time, quality, and delivery are essential.

What You'll Do

    • Work closely with multidisciplinary contributors to build a semi-automated cell engineering operation, focused on delivering custom engineered cell lines for research and customer needs.
    • Design sgRNA guides, ssODN/ssDNA donors, and primers for CRISPR/Cas9 knock-in and knock-out experiments to ultimately deliver edited pools and clonal populations. 
    • Analyze imaging results and sequencing results as part of project execution.
    • Operate robotic instrumentation including liquid handling systems, microscopy tools and software, as well as standalone isolated expansion systems.
    • Independently execute on 10-15 production projects at any one time, while adhering to production timelines and turn around times. 
    • Provide project updates to the Scientific Project Manager and Scientific Operations Manager to ensure customers are up to date regarding progress and expected delivery dates.
    • Document project related design, progress, and results in Laboratory Information Management System (LIMS) real time. 
    • Assist in the generation of production Standard Operating Procedures (SOPs) to enable technical transfer to the Production team. 
    • Generate Quality Documents and Reports as part of project completion. 
    • Work closely with the Systems Engineering team to develop and optimize protocols for CRISPR experiments and cell imaging methods
    • Supervise cell culture specialists and research associates as required.  
    • Track new techniques and technologies in CRISPR genome editing space

About You

    • Ph.D. in synthetic/molecular biology, biochemistry, or bioengineering or M.S. with comparable years of experience.
    • 3 - 5 + years of life sciences wet lab experience including operating scientific instrumentation and/or manufacturing environment
    • Significant experience with mammalian cell culture and clonal cell population generation. 
    • Experience culturing and editing different mammalian cell types including human immortalized cells and primary cells. Familiarity with both suspension and adherent cell lines at small scale required. 
    • Demonstrated experience designing guides and donors for CRISPR/Cas9 editing, as well as analyzing results from Sanger Sequencing.
    • Strong molecular biology skills including handling and purification of gDNA, PCR design and execution, RNA isolation, and molecular cloning skills
    • Experience developing and optimizing scientific protocols or Standard Operating Procedures.
    • Ability to contribute to the design and analysis of experimental procedures by incorporating the views of others to conduct where appropriate in parallel more than one agreed area of work to agreed timelines
    • Looking for an energetic production startup environment 
    • Innovative publications and excellent oral and written communication skills and organizational skills

Nice to Haves

    • Fluorescence microscopy and/or FACS
    • Experience in culturing difficult cell lines and induced pluripotent stem cells (iPSCs)
    • Automation robotics and high-throughput experience
    • NGS library prep and data analysis
    • Manufacturing & Core Facilities environment
    • Worked directly with LIMS system or batch production record

Company Perks & Benefits

    • Competitive salary
    • Generous equity at an early stage company
    • Robust medical, dental and vision benefits
    • 401k Plan
    • Fully stocked kitchen and snacks
    • Onsite gym
    • Free catered lunches and dinners 
    • 4x daily Shuttle bus to & from San Francisco
Synthego’s vision is to turn biology into an information science, with the ultimate goal of dramatically extending the healthy human lifespan.
Synthego builds advanced bioinformatics and automated hardware platforms to create next-generation molecular biology tools, starting with full-stack genome engineering.