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Protocol Development Scientist, Scale Up Chemistry at Synthego
Redwood City, CA, US
Synthego’s Engineering team prides itself in its breadth of skill sets and expertise that are largely responsible for new product and infrastructure development. To accomplish this, they have combined engineering, automation and science to solve the problems that no single  discipline could tackle alone.
As a Protocol Development Scientist within Synthego’s Engineering Team, you will help set the foundation of Synthego’s fully automated, cloud-enabled, molecular biology lab. You will be heavily involved in process and product improvements, as well as new product development, taking on both the scientific challenges of process launches and characterisation, as well as key project coordination responsibilities.

What You'll Do

    • Work with an interdisciplinary team to optimize methods for the preparation and purification of synthetic RNA via automated solid-phase synthesis
    • Design and execute studies and data gathering exercises, with the aim of adapting new and existing protocols for synthesis scale-up in a high-throughput synthesis factory.
    • Create a broad set of analytical tools and use them to make targeted improvements to automated systems performing high throughput chemistry across multiple labs / environments.
    • Maintain expertise on current literature, alternate methods, techniques and best practices used in the field; routinely benchmark process performance.
    • Create novel assays and analytical techniques to troubleshoot and quantify chemical intermediates in the synthesis and processing pipeline.
    • Handle multiple projects, seeing obvious overlaps to make the implementation process more efficient and standardized.
    • Gather requirements, create specifications, and document appropriately for the engineering teams
    • Support production activities; offer insight into troubleshooting methodology and problem resolution with complex instrumentation, systems or processes.
    • Provide analytical support to QC, Process Engineering and Manufacturing as applicable.
    • Aid software integration of all the products and protocols you develop: In a large-scale, distributed, fully-automated genome factory, centralization of data is critical.
    • Supervise and train junior team members in best practices and standardized methodologies.
    • Work with Synthego’s custom hardware platforms and help push scientific boundaries forward.

About You

    • Masters or PhD (preferred) in a relevant chemistry discipline: Organic Synthesis, Analytical Chemistry, Synthetic Biology
    • 3+ years post-doctoral experience (or 5+ with Masters) in automated solid-phase synthesis, purification and analysis of oligonucleotides
    • No matter how simple the protocol, you’ve taken the time to understand the steps, constraints, and missing characterization work prior to creating a robust version for production
    • You understand the complexities and overhead of regulatory compliance - experience in GMP environment required
    • Getting a good result once doesn’t cut it - you’re always after a robust process that executes well each and every time (and if it doesn’t, knowing immediately why)
    • Familiarity with navigating and analyzing large data sets using Python, R, or analysis programs such as Tableau.
    • You are well-versed at the documentation overheads that come with doing good science - protocol definition write-up, reporting to external groups, and summarizations as would be required for publications
    • Multiple, medium-sized (quarter-long) projects running at the same time is something you are used to, both as an individual contributor and as project coordinator, and you’re looking to take on more
    • You have the ability to work diligently with minimal supervision and take initiative to drive project deadlines
    • You can work independently but consider yourself to be a team player

Nice To Haves

    • You may or may not have direct experience with CRISPR, but would understand its importance
    • Hands-on experience with liquid handling platforms (Tecan, Hamilton, Beckman)
    • Experience in a GMP/GLP environment
    • Experience with document control and design control
    • Hands-on experience in HPLC, GC, ESI, LCMS, and GCMS
Synthego’s vision is to turn biology into an information science, with the ultimate goal of dramatically extending the healthy human lifespan.
Synthego builds advanced bioinformatics and automated hardware platforms to create next-generation molecular biology tools, starting with full-stack genome engineering.
These world-class tools accelerate basic scientific discovery, critical disease cures and novel synthetic biology applications to improve and prolong life.