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Head of Protocol Development, Assays at Synthego
Redwood City, CA, US
Synthego’s Engineering team prides itself in its breadth of skill sets and expertise that are largely responsible for new product and infrastructure development. To accomplish this, they have combined engineering, automation and science to solve the problems that no one discipline could tackle alone. As a Head of Protocol Development, Assays within Synthego’s Engineering Team, you will champion the scientific foundation of Synthego’s fully automated, cloud-enabled, screening lab. You will be heavily involved in building a process and implementation automation, taking on both the scientific challenges of assay characterization and launching these into production.

What You'll Do

    • Automate the screening of edited cell lines in a state of the art CRISPR facility
    • Guide the design and execution of studies in order to understand new and existing assays for use in a scalable factory
    • Lay the groundwork for the screening of edited iPSC cell lines, and testing their compatibility with automation
    • Drive the buildout of flexible automation, enabling transition of new functional assays from our R&D teams into production
    • Maintain expertise on alternate methods, techniques and best practices used in the field; routinely benchmark process performance
    • Create a broad set of analytical tools and use them to make targeted improvements to automated systems across multiple labs / environments
    • Evaluate critical tradeoffs and make decisions on resource requirements and allocations to set high-level initiative goals 
    • Handle multiple projects, seeing obvious overlaps to make the implementation process more efficient and standardized
    • Gather requirements, create specifications, and document appropriately for the engineering teams
    • Support production activities; offer insight into troubleshooting methodology and problem resolution with complex instrumentation, systems or processes
    • Ensure all work and results are recorded suitably for regulatory compliance
    • Aid software integration of all the products and protocols you develop: In a large-scale, distributed, fully-automated cell line engineering factory, centralization of data is critical
    • Supervise and train junior team members in best practices and standardized methodologies
    • Work with Synthego’s custom hardware platforms and learn what it means to push scientific boundaries forward

About You

    • Masters or PhD (preferred) in a Life / Physical Science
    • 10 years experience investigating, developing, and implementing automated laboratory or manufacturing processes
    • 3+ years of managing a technical team of scientists / engineers 
    • You have set up automated screening platforms so many times, you can teach the pitfalls of various methodologies to other departments
    • You appreciate the difference between functional and target identification screening
    • No matter how simple the protocol, you’ve taken the time to understand the steps, constraints, and missing characterisation work prior to creating a supportable version for production
    • Getting a good result once doesn’t cut it - you’re always after a robust process that executes well each and every time (and if it doesn’t, knowing immediately why)
    • You understand how important well-defined qualifications are to the life-cycle of a product - IQ/OQ/PQ aren’t just letters, they are a way of life 
    • You are familiar with the experimental and documentation overheads that come with being in a regulatory environment (cGxP, CLIA, CAP, ISO)
    • You’ve seen a team be created, guided it through getting to know itself, and taken the time to understand what drives its members
    • Multiple, medium-sized (quarter-long) projects running at the same time is something you are used to, both as an individual contributor and as project coordinator, and you’re looking to take on more
    • You have the ability to work diligently with minimal supervision and take initiative to drive project deadlines
    • You are meticulous in capturing goals, to-dos, and decisions made for yourself and those around you
    • You can work independently but consider yourself to be a team player

Nice to Haves

    • Broad knowledge of statistics / analytical methods
    • You can provide evidence of working with Biology / Chemistry at scale

Company Benefits & Perks

    • Competitive salary
    • Generous equity at an early stage company
    • Robust medical, dental and vision benefits
    • 401k Plan
    • Fully stocked kitchen and snacks
    • Free catered lunches and dinners 
    • 4x daily Shuttle bus to & from San Francisco
ABOUT SYNTHEGO
 
Synthego’s vision is to turn biology into an information science, with the ultimate goal of dramatically extending the healthy human lifespan.
 
Synthego builds advanced bioinformatics and automated hardware platforms to create next-generation molecular biology tools, starting with full-stack genome engineering.
 
These world-class tools accelerate basic scientific discovery, critical disease cures and novel synthetic biology applications to improve and prolong life.